You will find a release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors during the dorsal horn to minimize afferent pain transmission and generate analgesia. Thus, medication like clonidine that concentrate on alpha-two receptors can affect the transmission of agony. Relates to clonidine: oral tablet, https://adamn257nid5.wikibuysell.com/user