Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts in the microenvironment and escalating the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have identified recurrent mutations in genes regulating tumor cell-microenvironment interactions, which c... https://irvingm420ira8.bloggip.com/profile