Environmental or self-antigens and homotypic interactions result in BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other signals within the microenvironment and raising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic experiments have determined recurrent mutations in genes regulating tumor cell-microenvironment interaction... https://normanu652oxf0.wikipowell.com/user