Thinking of the active intermediates, the crown ether ring of icotinib is oxidated to open up to type an aldehyde; the indolylidene ring of famitinib is oxidated accompanied by rearrangement to type a quinone- imine; the α, β-unsaturated carbonyl team of allitinib is oxidated to type an epoxide, these intermediates https://lioydsmeds.com/product/buy-imbruvica-online/