Pentobarbital will reduce the extent or influence of alfentanil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unfamiliar. pentobarbital will decrease the level or result of darunavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Adhering to oral or parenteral administration, barbiturates easily cross the placenta... https://mahendran530gpw6.homewikia.com/user