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Opioid activity is due to the two minimal affinity binding in the mother or father compound and higher affinity binding in the O-demethylated metabolite M1 to μ-opioid receptors. In animal models, M1 is nearly six times far more strong than tramadol in making analgesia and 200 situations much more potent https://www.buyoltram.com/product/buy-tramadol-50-mg/

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