RANKL is actually a member with the tumor necrosis component (TNF) cytokine household, it binds to RANK on cells on the myeloid lineage and functions as a important variable for osteoclast differentiation and activation. RANKL may additionally bind to osteoprotegerin, a protein secreted largely by cells with the osteoblast lineage http://rank86917.designertoblog.com/24755901/details-fiction-and-rank